MP6 (TFA)

MP6 (Myr-FEEERA-OH) TFA is a myristoylated peptide. mP6 TFA inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 TFA can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells[1].

Myr-FEEERA-OH (TFA)

12352209

Integrin

Cytoskeleton

Infection

98.48

O=C(O)C(F)(F)F.O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(CCCCCCCCCCCCC)=O.[x]

C47H75N9O14.xC2HF3O2

990.15 (free base)

[1]Bondu V, et al. Low-affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection. Mol Biol Cell. 2017 Oct 15;28 (21) :2887-2903.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10038A/mP6-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported