MPYS Antilichaam

MPYS Antibody: MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.

340061

Q86WV6

NP_938023

Human, Mouse

5269

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar MPYS expression profile in human cell lines detected by two independent anti-MPYS antibodies that recognize different epitopes, 5269 against near C-terminus domain and 64-236 against C-terminus domain. MPYS proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines5269 64-236

Innate Immunity

MPYS Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat (82%), Bovine: (82%), Pig: (82%), Chicken: (71%)

MPYS Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MPYS antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human MPYS has one isoform (379aa, 42kD) . Mouse MPYS has 3 isoforms, including isoform 1 (379aa, 42kD), isoform 2 (427aa, 48kD) and isoform 3 (337aa, 38kD) . Rat MPYS also has one isoform (379aa, 43kD) . 5269 can detect human, mouse and rat.

TMEM173

Cat. No. 1205 - Jurkat Cell Lysate

Cat. No. 1288 - A20 Cell Lysate

Cat. No. 17-208 - A-20 Cell Slide

Transmembrane protein 173

Homo sapiens

Jin et al. Mol. Cell. Biol.2008; 28:5014-26.

Zhong et al. Immunity2008; 29:538-50.

MPYS Antibody: ERIS, MITA, MPYS, NET23, STING, ERIS, Stimulator of interferon genes protein, Endoplasmic reticulum interferon stimulator, hSTING

ELISA, WB, ICC, IF

38093659

Liquid