MRC1 Antilichaam / Macrofage mannose receptor 1 / MRC1L1

CD206, also known as macrophage mannose receptor type C (MMR, MRC1, MRC1L1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Immunohistochemistry (FFPE) : 1-2 µg/mL

P22897

Human

A portion of amino acids 1-200 from human Macrophage mannose receptor 1 protein was used as the immunogen for the MRC1 antibody.

MRC1/9454

IHC-P

Protein A/G affinity

Purified

This MRC1 antibody is available for research use only.

Aliquot the MRC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the MRC1 antibody should be determined by the researcher.

Cell membrane, cytoplasm

IHC staining of FFPE human lung tissue with MRC1 antibody (clone MRC1/9454) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.