MS4078
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2229036-62-6
C06981-5mg
ALK
Protein Tyrosine Kinase
CC1=CC (=C (C=C1C2CCN (CC2) CC (=O) NCCNC3=CC=CC4=C3C (=O) N (C4=O) C5CCC (=O) NC5=O) OC (C) C) NC6=NC=C (C (=N6) NC7=CC=CC=C7S (=O) (=O) C (C) C) Cl
C45H52ClN9O8S
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
3 years -20°C powder
Beschrijving
MS4078 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
Recent bekeken producten
Human Sertoli Cell Complete Medium
MBS2576755-01
100 mL
Urobilinogen protein
MBS5303823-01
100 mg
AffiniPure Goat Anti-Rabbit IgG H&L, HRP conjugated
GTR17765564-01
100 µL
Pribolab® Automatic Immunoaffinity Column Purification System
HWEQ-IM 5050
1 Unit
OneTaq Hot Start 2X Master Mix with GC Buffer
NEB M0485L
500 Reactions
HyperLadder 1kb
BIO-33053
100 Lanes
MicroMolar UDP assay kit - 100 assays
MUD100K
100 Assays
MEM Amino Acids Solution (50x) w/o: L-Glutamine
P08-30100
100 mL
Recent gezochte producten
Recombinant Human CD73 (T376A, M379T, C-Fc)
CW65-1mg
1 mg
Recombinant Human CD73 (T376A, M379T, C-Fc)
CW65-50ug
50 µg
Rabbit Monoclonal TdT Antibody (RM379)
NBP2-77436
100 µL
Mouse Monoclonal MCM7 Antibody (SPM379)
NBP2-53219-20ug
20 µg
Mouse Monoclonal MCM7 Antibody (SPM379)
NBP2-53219-100ug
100 µg
PEnter-NT5E (T376A/M379T) -Flag-His
PPL00480-2a
1 Each
MCM7 Antibody [SPM379]
33-735
100 µg
pEnter-NT5E(T376A/M379T)-Flag-His Plasmid
PVTB00480-2a
2 µg