MSH2 Antilichaam [3A2B8C]

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC) . The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI) . These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.

4436

P43246

P43246

Human

Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3) .

3A2B8C

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

MSH2 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

MSH2

MutS homolog 2

Homo sapiens

Papadopoulos, N. 1994. Science 263: 1625-1629.

Palombo, F. 1994. Nature 367:417-418.

MutS protein homolog 2, hMSH2, FCC1, COCA1, HNPCC, LCFS2, HNPCC1

ELISA, WB, IHC

1171032