MSH4 Antilichaam

This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

4438

O15457

Human, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 697-936 of human MSH4 (NP_002431.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

SKOV3

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 105kDa

IgG

MSH4

MutS homolog 4

Homo sapiens

MSH4, mutS homolog 4 (E. coli), RP11-262K24.2, mutS homolog 4

WB, IF

Liquid