MSH6 Mouse Monoclonal Antibody [Kloon ID: LBI5D1]

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Carrier-free (BSA/glycerol-free) MSH6 mouse monoclonal antibody, clone LBI5D1

GTBP; GTMBP; HNPCC5; HSAP; MMRCS3; p160

Homo sapiens mutS homolog 6 (MSH6), transcript variant 1, mRNA.

2956

P52701

Unconjugated

Colorectal cancer, Mismatch repair, Pathways in cancer

Colorectal cancer, Mismatch repair, Pathways in cancer

WB 1:2000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Stem cell - Pluripotency

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

MSH6

https://www.ncbi.nlm.nih.gov/gene/?term=2956

https://www.uniprot.org/uniprot/P52701