MSH6 (NM 000179) Humaan Recombinant Proteïne

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

Purified recombinant protein of Human mutS homolog 6 (E. coli) (MSH6), Met1-Ser280, with N-terminal His tag, expressed in E. coli, 50ug

GTBP; GTMBP; HNPCC5; HSAP; MMRCS3; p160

2956

P52701, Q3SWU9

NM_000179

2p16.3

E. coli

N-His

Colorectal cancer, Mismatch repair, Pathways in cancer

Colorectal cancer, Mismatch repair, Pathways in cancer

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0

Druggable Genome, Stem cell - Pluripotency

30.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

MSH6

Human

NP_000170

https://www.ncbi.nlm.nih.gov/gene/2956

https://www.uniprot.org/uniprot/P52701

https://www.ncbi.nlm.nih.gov/nuccore/NM_000179

https://www.ncbi.nlm.nih.gov/nuccore/NP_000170