MTA1 Antilichaam - middengebied: HRP (ARP37737_T100-HRP)

Metastasis associated 1

9112

Q13330-2

AAN01613

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human MTA1

MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. MTA1 was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

KRT40; LZTS2; IKZF1; SH3GL1; SAT1; RBBP4; MAGEA11; KPNA3; NOTCH2NL; KRTAP10-8; KHDRBS2; SUMO2; SUMO3; DNMT3B; DNMT1; NACC2; UBC; SUZ12; EED; RNF2; HIC1; SOX2; HDAC2; HDAC1; HIST3H3; GATAD2B; MBD3; KDM1A; POLD3; MTA2; NR2C2; NR2C1; CHD4; UBE2I; HIST2H3C; B

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

MTA1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Kumar, R., et al., (2002) Nature 418 (6898), 654-657

Wet Ice

430

MTA1

MTA1

Rabbit

Metastasis-associated protein MTA1

NM_001203258

QQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYN