MTCH2 Antilichaam

MTCH2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway.

56428

Q791V5

NP_055157

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

MTCH2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (75%)

MTCH2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MTCH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Mtch2

Mitochondrial carrier homolog 2 (C. elegans)

Mus musculus

Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ.2000; 7:2-7.

Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene2003; 22:8590-607.

Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.2004; 39:1125-35.

Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol.2005; 25:4579-90.

MTCH2 Antibody: HSPC032, 2310034D24Rik, 4930539J07Rik, Mitochondrial carrier homolog 2

ELISA, WB, IHC-P, IF

5815347

Liquid