MUC13 Antilichaam / Mucin 13

Mucins are epithelial glycoproteins with a high content of clustered oligosaccharides that are O-glycoside linked to tandem repeat peptides rich in threonine, serine and proline. Mucin 13 (MUC13), also designated downregulated in colon cancer 1 (DRCC1), is an epithelial and hemopoietic type I membrane protein that undergoes secretion and influences gastrointestinal mucosa levels. It is most abundant in epithelial tissues of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach. Mucin 13 is a good differentiation marker for gastrointestinal mucosa and may also indicate certain gastric tumors. It localizes to the apical membrane of both columnar and goblet cells in the gastrointestinal tract, and within goblet cell thecae. Mucin 13 is a cleaved protein, and the b subunit, containing the cytoplasmic tail, can homodimerize.

Immunohistochemistry (FFPE) : 1-2 µg/mL

Q9H3R2

Human

A portion of amino acids 100-300 from human Mucin 13 protein was used as the immunogen for the MUC13 antibody.

MUC13/13111

IHC-P

Protein G affinity

Purified

This MUC13 antibody is available for research use only.

Aliquot the MUC13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the MUC13 antibody should be determined by the researcher.

Cell membrane

IHC staining of FFPE human small intestine tissue with MUC13 antibody (clone MUC13/13111) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.