Mucin 13 Antilichaam / MUC13

Mucins are epithelial glycoproteins with a high content of clustered oligosaccharides that are O-glycoside linked to tandem repeat peptides rich in threonine, serine and proline. Mucin 13 (MUC13), also designated downregulated in colon cancer 1 (DRCC1), is an epithelial and hemopoietic type I membrane protein that undergoes secretion and influences gastrointestinal mucosa levels. It is most abundant in epithelial tissues of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach. Mucin 13 is a good differentiation marker for gastrointestinal mucosa and may also indicate certain gastric tumors. It localizes to the apical membrane of both columnar and goblet cells in the gastrointestinal tract, and within goblet cell thecae. Mucin 13 is a cleaved protein, and the b subunit, containing the cytoplasmic tail, can homodimerize.

Immunohistochemistry (FFPE) : 1-2 µg/mL

Q9H3R2

Human

A portion of amino acids 100-300 from human Mucin 13 protein was used as the immunogen for the Mucin 13 antibody.

MUC13/13113

IHC-P

Protein A affinity

Purified

This Mucin 13 antibody is available for research use only.

Aliquot the Mucin 13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the Mucin 13 antibody should be determined by the researcher.

Cell membrane, Cytoplasm, Secreted

IHC staining of FFPE human small intestine tissue with Mucin 13 antibody (clone MUC13/13113) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.