Musk (fosfo Tyr755) Antilichaam

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

4593

O15146

NP_005583.1

Human, Mouse, Rat

MuSK (phospho Tyr755) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 755 (A-D-Y (p) -Y-K) derived from Human MuSK .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

97 kDa

IgG

The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755.

Western Blot: 1:500~1:1000

MUSK

Muscle, skeletal, receptor tyrosine kinase

Homo sapiens

Valenzuela D.M., Neuron 15:573-584 (1995) .

Humphray S.J., Nature 429:369-374 (2004) .

Bergamin E., Mol. Cell 39:100-109 (2010) .

MUSK, Muscle, skeletal

WB

5031927

Liquid