MUTYH Antilichaam

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP) . Multiple transcript variants encoding different isoforms have been found for this gene.

4595

Q9UIF7

Human, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

MUTYH

MutY homolog

Homo sapiens

MUTYH, MYH, mutY homolog (E. coli), mutY (E. coli) homolog

IHC, IF

Liquid