MYBPC2 Antilichaam

MYBPC2 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.

4606

Q14324

EAW71866

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

MYBPC2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (91%)

MYBPC2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MYBPC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MYBPC2

Myosin binding protein C, fast type

Homo sapiens

Weber FE, Vaughan KT, Reiach FC, et al. Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C) . Differential expression, conserved domain structure and chromosome assignment. Eur. J. Biochem.1993; 216:661-9.

Konhilas JP, Irving TC and De Tombe PP. Length-dependent activation in three striated muscle types of the rat. J. Physiol.2002; 544:225-36.

Flashman E, Korkie L, Watkins H, et al. Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. FEBS Lett.2008; 582:434-8.

MYBPC2 Antibody: MYBPC, MYBPCF, Myosin-binding protein C, fast-type, C-protein, skeletal muscle fast isoform, Fast MyBP-C

ELISA, WB, IHC-P

119592272

Liquid