MyD88 Antilichaam [2E9C2]

MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κ B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

4615

Q99836

AAC50954

Human, Mouse

Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.

2E9C2

Unconjugated

Primary Antibodies

Innate Immunity, Inflammasomes

MyD88 Monoclonal Antibody is Protein A purified.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

MyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MyD88 monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG2b

MYD88

Cat. No. 95-104 - MyD88 Recombinant Protein

Cat. No. 10-501 - Human Heart Tissue Slide

Myeloid differentiation primary response gene (88)

Homo sapiens

Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5.

Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998; 9:143-50.

Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 1998; 2:253-8.

Kawai T, Adachi O, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-22.

MyD88 Antibody [2E9C2] : MYD88D

ELISA, WB, IHC-P, IF

1814020

Liquid