Myeline Basiseiwit Antilichaam

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

4155

P02686

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human Myelin Basic protein (NP_001020271.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience, Stem Cell

Affinity purification

NB4

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 17kDa/33kDa/40kDa

IgG

MBP

SH-SY5Y

HL-60

HT-29

PC-3

PC-12

Myelin basic protein

Homo sapiens

MBP, Myelin A1 protein, Myelin basic protein

WB, IHC

Liquid