MYH3 Antilichaam

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1) . MYH3 (myosin, heavy chain, skeletal muscle, embryonic) plays a significant role in skeletal muscle development (2) and is also essential for the proper morphology and function of the developing heart (3) . Mutations in this gene have been associated with Freeman-Sheldon syndrome and Sheldon-Hall syndrome (4) .

4621

P11055

NP_002461

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

MYH3 antibody is affinity chromatography purified via peptide column.

Cat. No. XBL-10413 - Fetal Human Skeletal Muscle Lysate

1 mg/mL

MYH3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MYH3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MYH3 antibody is human, mouse and rat reactive. MYH3 antibody is predicted to not cross-react with other members of the myosin heavy chain family.

MYH3

Myosin, heavy chain 3, skeletal muscle, embryonic

Homo sapiens

Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.

Lagrutta AA, McCarthy JG, Scherczinger CA, et al. Identification and developmental expression of a novel embryonic myosin heavy-chain gene in chicken. DNA 1989; 8:39-50.

Rutland CS, Polo-Parada L, Ehler E, et al. Knockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heart. Development 2011; 138:3955-66.

Toydemir RM, Rutherford A, Whitby FG, et al. Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nat. Genet. 2006; 38:561-5.

Myosin heavy chain 3, Myosin-3, Myosin heavy chain skeletal muscle embryonic, HEMHC, MYHC-EMB, MYHSE1, SMHCE

ELISA, WB, IHC-P

98986453

Liquid