MYH8 Antilichaam

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells (1) . MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal) is a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction (2,3) . This gene is predominantly expressed in fetal skeletal muscle. MYH8 is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations (3) . A mutation in this gene results in trismus-pseudocamptodactyly syndrome (4) .

4626

P13535

NP_002463

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

MYH8 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Horse: (95%), Rabbit: (95%), Pig: (89%), Bovine: (89%), Chicken: (89%)

MYH8 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MYH8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MYH8 antibody is human, mouse and rat reactive. MYH8 antibody is predicted to not cross-react with other members of the myosin heavy chain family.

MYH8

Myosin, heavy chain 8, skeletal muscle, perinatal

Homo sapiens

Yu H, Waddell JN, Kuang S, et al. Park7 expression influences myotube size and myosin expression in muscle. PLoS One 2014; 9:e92030.

Feghali R and Leinwand LA. Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain. J. Cell Biol. 1989; 108:1791-7.

Jullian EH, Kelly AM, Pompidou AJ, et al. Characterization of a human perinatal myosin heavy-chain transcript. Eur. J. Biochem. 1995; 230:1001-6.

Minzer-Conzetti K, Wu E, Vargervik K, et al. Phenotypic variation in trismus-pseudocamptodactyly syndrome caused by a recurrent MYH8 mutation. Clin. Dysmorphol. 2008; 17:1-4.

Myosin heavy chain 8, Myosin-8, Myosin heavy chain skeletal muscle perinatal, MyHC-perinatal, MyHC-peri, MyHC-pn, gtMHC-F

ELISA, WB, IHC-P, IF

153945790

Liquid