Myosine-bindend eiwit C Antilichaam / MYBPC3

Myosin-binding protein C is a thick filament-associated protein that interacts with myosin and actin to regulate muscle contraction. It acts as a molecular ruler, fine-tuning the interactions between myosin and actin to ensure proper muscle function. MYBPC3 mutations can disrupt this delicate balance, leading to impaired muscle contraction and potential cardiac complications. Mutations in the MYBPC3 gene have been associated with hypertrophic cardiomyopathy (HCM), a condition characterized by thickening of the heart muscle. These mutations can disrupt the normal function of Myosin-binding protein C, leading to abnormal muscle contraction and potentially life-threatening complications.

Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:25

Q14896

Human, Mouse, Rat

A portion of amino acids 189-218 from the human protein was used as the immunogen for the Myosin-binding protein C antibody.

WB, IHC-P

Antigen affinity

Purified

This Myosin-binding protein C antibody is available for research use only.

Aliquot the Myosin-binding protein C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the Myosin-binding protein C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

IHC staining of FFPE human heart tissue with Myosin-binding protein C antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.