Myristinine B/C

Myristinin B/C is a mixture of Myristinin B and Myristinin C. Myristinin B/C is a flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin B/C can selectively inhibit COX-2 activity with an IC50 of 2.1 μg/mL. Myristinin B/C can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin B/C can inhibit Candida albicans with an IC50 of 6 μg/mL. Myristinin B/C can be used for the research of inflammation and infection, such as rheumatoid arthritis[1].

12352005

COX; Fungal; Prostaglandin Receptor

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Infection; Inflammation/Immunology

OC1=C([C@@H]2C3=CC=C(C=C3O[C@@H](C2)C4=CC=C(O)C=C4)O)C(O)=CC(O)=C1C(CCCCCCCCCCC)=O

C33H40O7

548.67

[1]Sawadjoon S, et al. Atropisomeric myristinins: selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea. J Org Chem. 2002 Aug 9;67 (16) :5470-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16865/

Natural Products

No Development Reported

COX-2