MYST1 Antilichaam [8C444]

MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone.

84148

Q9H7Z6

Q9H7Z6

Human

Ni-NTA purified truncated recombinant MYST1-trx expressed in E. Coli strain BL21 (DE3) .

8C4C4

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

MYST1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2b

KAT8

K (lysine) acetyltransferase 8

Homo sapiens

Sterner, D.E., et al. Microbiol. Mol. Biol 2000 Rev. 64: 435-459.

Neal, K.C., et al. Biochim. Biophys. 2000 Acta 1490: 170-174.

Akhtar, A., et al. EMBO 2001 Rep. 2: 113-118.

MOF, MYST1, PP7073, Lysine acetyltransferase 8, MYST-1, MOF, hMOF, ZC2HC8

ELISA, WB

68565938