N-acetyl-D-glucosamine-d3

N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits[1][2][3].

77369-11-0

N-Acetyl-2-amino-2-deoxy-D-glucose-d3

12352211

Drug Derivative; Drug Isomer; Endogenous Metabolite; Interleukin Related; Isotope-Labeled Compounds

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Metabolism-protein/nucleotide metabolism

Cancer; Metabolic Disease; Inflammation/Immunology

O=C[C@@H]([C@@H](O)[C@H](O)[C@H](O)CO)NC(C([2H])([2H])[2H])=O

C8H12D3NO6

224.23

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Simonetti N, et al. Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans. Nature. 1974 Jul 26;250 (464) :344-6.|[3]Masuda S, et al. Anti-tumor properties of orally administered glucosamine and N-acetyl-D-glucosamine oligomers in a mouse model. Carbohydr Polym. 2014 Oct 13;111:783-7.|[4]Tamai Y, et al. Enhanced healing of cartilaginous injuries by N-acetyl-d-glucosamine and glucuronic acid[J]. Carbohydrate Polymers, 2003, 54 (2) : 251-262.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0132S14/

Isotope-Labeled Compounds

No Development Reported