N-acetyl-L-arginine (standaard)

N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of a hemodialyzed renal insufficient (uremic) pediatric population. N-Acetyl-L-arginine shows synergistic activity with glycine buffer. N-Acetyl-L-arginine suppresses the aggregation of intravenous immunoglobulins with a minimum decrease in transition temperature. N-Acetyl-L-arginine dramatically reduces IL-1 expression in the presence of silicone oil. N-Acetyl-L-arginine also demonstrates colloidal stability[1][2][3].

155-84-0

12352211

Endogenous Metabolite

Metabolic Enzyme/Protease

Others

O=C(C)N[C@@H](C(O)=O)CCCNC(N)=N

C8H16N4O3

216.24

[1]De Deyn PP, et al. Serum guanidino compound levels in uremic pediatric patients treated with hemodialysis or continuous cycle peritoneal dialysis. Correlations between nerve conduction velocities and altered guanidino compound concentrations. Nephron. 1995;69 (4) :411-7.|[2]Kim, N. A., et al., (2022) . Enhanced protein aggregation suppressor activity of N-acetyl-l-arginine for agitation-induced aggregation with silicone oil and its impact on innate immune responses. International journal of biological macromolecules, 216, 42–51.|[3]Kim, N. A., et al., (2021) . N-Acetylated-L-arginine (NALA) is an enhanced protein aggregation suppressor under interfacial stresses and elevated temperature for protein liquid formulations. International journal of biological macromolecules, 166, 654–664.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W014130R/

Reference Standards