Nε- (Carboxyethyl) lysine

Nε- (Carboxyethyl) lysine is an advanced glycation end product (AGE) . Nε- (Carboxyethyl) lysine causes cross-linking between proteins, affects the structure and function of proteins, and leads to protein denaturation. Nε- (Carboxyethyl) lysine binds to RAGE receptors, affects cell signaling, regulates processes such as inflammatory response, cell proliferation and apoptosis. Nε- (Carboxyethyl) lysine affects glutamate transporter, reduces glutamate uptake and S100B protein secretion, affects neurotransmission in the nervous system, and exhibits diabetic-related neurotoxicity[1][2].

5746-03-2

12352211

H302, H315, H319, H335

EAAT

Membrane Transporter/Ion Channel

Neuroscience-Neuromodulation

Neurological Disease

99.9

N[C@@H](CCCCNC(C(O)=O)C)C(O)=O

C9H18N2O4

218.25

H302, H315, H319, H335

[1]Ahmed MU, et al., N-epsilon- (carboxyethyl) lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J. 1997 Jun 1;324 (Pt 2) (Pt 2) :565-70. |[2]Hansen F, et al., Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids. 2016 Feb;48 (2) :375-85.

Blue Ice

-20°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-W585874/Nε-Carboxyethyl-lysine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported