N-Deacetyl-N-formylcolchicine

N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors[1].

7411-12-3

N-Formyl-N-deacetylcolchicine

12352005

H300-H318-H330-H340

Apoptosis; Microtubule/Tubulin

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Cancer

COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)NC=O)=C3)=CC=C(OC)C3=O

C21H23NO6

385.41

P260-P264-P270-P271-P280-P284-P304+P340-P305+P351+P338-P330-P403+P233-P405-P501

[1]Goel B, et al. Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development. ACS Omega. 2022 Aug 12;7 (33) :28994-29001.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-Z8644/

Reference compound2

No Development Reported