N-Deschloorbenzoylindomethacine
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin , lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].
2882-15-7
12352005
H302, H315, H319, H335
Drug Metabolite
Metabolic Enzyme/Protease
Metabolism-protein/nucleotide metabolism
Others
97.0
CC(N1)=C(C2=C1C=CC(OC)=C2)CC(O)=O
C12H13NO3
219.24
H302, H315, H319, H335
[1]Liedtke AJ, et al. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. J Med Chem. 2013 Mar 28;56 (6) :2429-46.
Room Temperature
Store at room temperature 3 years
http://file.medchemexpress.com/batch_PDF/HY-W008567/N-Deschlorobenzoyl-indomethacin-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin , lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Desc
Specificaties
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