N-Formylkynurenine

N-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine. The formation of N-formylkynurenine is catalyzed by heme dioxygenases.

1022-31-7

12352005

H302, H315, H319

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolic Disease

98.50

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

O=CNC1=C(C(CC(C(O)=O)N)=O)C=CC=C1

C11H12N2O4

236.22

H302, H315, H319

[1]Wang Y, Leung E, Tomek P. N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway. Bioorg Chem. 2025 Mar;156:108219. |[2]Basran J, Efimov I, Chauhan N, Thackray SJ, Krupa JL, Eaton G, Griffith GA, Mowat CG, Handa S, Raven EL. The mechanism of formation of N-formylkynurenine by heme dioxygenases. J Am Chem Soc. 2011 Oct 12;133 (40) :16251-7.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-28247/N-Formylkynurenine-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported