N'-Isonicotinoylisonicotinohydrazide

N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC50=5-30 μM) of bacterial heme oxygenase (HO) . N'-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N'-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N'-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections[1][2].

4329-75-3

1,2-Diisonicotinoylhydrazine

12352005

H228

Bacterial; Reactive Oxygen Species (ROS)

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Infection

99.55

O=C(C1=CC=NC=C1)NNC(C2=CC=NC=C2)=O

C12H10N4O2

242.23

H228

[1]Furci LM, et al. Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. J Med Chem. 2007 Aug 9;50 (16) :3804-13.|[2]Panda SS, et al. Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid-isoniazid hybrid conjugates. RSC Adv. 2019 Jul 1;9 (35) :20450-20462.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W354203/

Reference compound2

No Development Reported