N-methylmesoporfyrine IX (oplossing)

N-Methylmesoporphyrin IX (NMM) (solution), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1].Solvent and concentration: DMSO: 2 mM

142234-85-3

G-quadruplex

Cell Cycle/DNA Damage

Neurological Disease

O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4C)/C(CC)=C(C)C4=C\C5=N/C(C(C)=C5CC)=C\C(N2)=C1C)=N/3.O=C(O)CCC6=C7/C=C8C(CCC(O)=O)=C(C)C(/C=C(N/9)/C(CC)=C(C)C9=C\C%10=N/C(C(C)=C%10CC)=C\C(N7C)=C6C)=N/8

C70H80N8O8

1161.46

[1]Meng Li, et al. N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer's Disease β-Amyloid Aggregation in Living Cells. ACS Chem Neurosci. 2017 Jun 21;8 (6) :1299-1304.

Blue Ice

Store at -20°C for 1 year, protect from light. Avoid repeated freezing and thawing

http://file.medchemexpress.com/batch_PDF/HY-DY1075/N-Methylmesoporphyrin-IX-solution-SDS-MedChemExpress.pdf

Dye Reagents

No Development Reported