N-Nitrosonornicotine-d4

N-Nitrosonornicotine-d4 ((2S) -N'-Nitrosonornicotine-d4) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].

1426174-36-8

(2S) -N'-Nitrosonornicotine-d4

12352005

DNA/RNA Synthesis; Isotope-Labeled Compounds

Cell Cycle/DNA Damage; Others

Cancer-programmed cell death

Cancer

[2H]C1=C(C([2H])=NC([2H])=C1[C@@H]2CCCN2N=O)[2H]

C9H7D4N3O

181.23

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774.|[3]Shugo Suzuki, et al. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. 2020 Jan 15:429:152325.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W743781/

Isotope-Labeled Compounds

No Development Reported