N-RAS Antilichaam

N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

4893

P01111

NP_002515

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

N-RAS Antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 – A431 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Guinea pig: (93%), Chicken: (80%)

N-RAS Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

N-RAS antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

N-RAS antibody is predicted to not cross-react with H-RAS

NRAS

Neuroblastoma RAS viral (v-ras) oncogene homolog

Homo sapiens

Ehrhardt A, Ehrhardt GR, Guo X, et al. Ras and relatives--job sharing and networking keep an old family together. Exp. Hematol. 2002; 30:1089-106.

Swarthout JT, Lobo S, Farh L, et al. DHHC9 and GCP9 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J. Biol. Chem. 2005; 280:31141-8.

Malaney S and Daly RJ. The ras signaling pathway in mammary tumorigenesis and metastasis. J. Mammary Gland Biol. Neoplasia 2001; 6:101-13.

Rodenhuis S. ras and human tumors. Semin Cancer Biol. 1992; 3:241-7

N-RAS Antibody: NS6, ALPS4, N-ras, NRAS1, HRAS1, GTPase NRas, Transforming protein N-Ras

ELISA, WB

4505451

Liquid