N4-Acetylcytidine-13C5

N4-Acetylcytidine-13C5 is the 13C-labeled N4-Acetylcytidine. N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity[1][2][3][4][5].

12352005

Endogenous Metabolite; Enterovirus; Histone Acetyltransferase; Isotope-Labeled Compounds; NOD-like Receptor (NLR)

Anti-infection; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Metabolism-protein/nucleotide metabolism

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

95.92

O=C(N=C(NC(C)=O)C=C1)N1[13C@@H]2O[13C@H]([13CH2]O)[13C@@H](O)[13C@H]2O

C6 13C5H15N3O6

290.22

[1]Zhang H, et al. N4-acetylcytidine modifies primary microRNAs for processing in cancer cells. Cell Mol Life Sci. 2024 Feb 3;81 (1) :73.|[2]Duan J, et al. N4-acetylcytidine is required for sustained NLRP3 inflammasome activation via HMGB1 pathway in microglia. Cell Signal. 2019 Jun;58:44-52.|[3]Hao H, et al. N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71. Nucleic Acids Res. 2022 Sep 9;50 (16) :9339-9354. |[4]Wan X, et al. NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis. Cell Death Differ. 2025 Mar 23.|[5]Zhao CC, et al. NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression. Thorac Cancer. 2024 Apr;15 (10) :820-829.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W753593/N4-Acetylcytidine-13C5-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported