NAcM-OPT
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro) .1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
Unconjugated
White solid
-20°C
Beschrijving
NAcM-OPT Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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