NADPH (tetranatriumzout)

NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication[1][2][3][4].

2646-71-1

12352005

H302, H315, H319, H335

Endogenous Metabolite; Ferroptosis

Apoptosis; Metabolic Enzyme/Protease

Cancer-programmed cell death

Cancer; Metabolic Disease

99.99

H2O : 125 mg/mL (ultrasonic)

O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O[Na])(O[Na])=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O[Na])=O)(O[Na])=O

C21H26N7Na4O17P3

833.35

H302, H315, H319, H335

[1]Tedeschi PM, et al. NAD+ Kinase as a Therapeutic Target in Cancer. Clin Cancer Res. 2016;22 (21) :5189-5195.|[2]Ng CY, F et al. Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration. Metab Eng. 2015;29:86-96.|[3]Ju HQ, Lin JF, et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020;5 (1) :231. Published 2020 Oct 7.|[4]Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171 (2) :273-285.

Blue Ice

-20°C (Powder, stored under nitrogen, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-F0003/NADPH-tetrasodium-salt-SDS-MedChemExpress.pdf

Oligonucleotides

No Development Reported

Human Endogenous Metabolite

Cell Rep Phys Sci. 2025 Mar 19.|Chem Biol Interact. 2022 Dec 1:368:110222.|Chemrxiv. 2025 Aug 28.|Drug Des Devel Ther. 2020 Nov 30;14:5259-5273.|Eur J Pharm Sci. 2021 Sep 1:164:105889.|iScience. 2024 Aug 30;27 (9) :110834.|JID Innov. 2023 Nov 28;4 (2) :100251.|Microbiol Spectr. 2023 Sep 21;11 (5) :e0267123.|Mol Ther Oncol. 2024 Sep 17;32 (4) :200878.|Research Square Preprint. 2023 Jul 31.|Xenobiotica. 2022 Feb;52 (2) :165-176.|Adv Sci (Weinh) . 2025 Sep 15:e07283.|J Agric Food Chem. 2024 Sep 11;72 (36) :20064-20076.