Nampt-IN-10

Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity[1].

2241015-68-7

12352005

ADC Payload; NAMPT

Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease

Cancer-programmed cell death

Cancer

FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O

C27H28FN5O2

473.54

[1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9 (8) :838-842.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W1117786/

Reference compound1

No Development Reported