Natrium-2-hydroxypentaandioaat-2,3,3-d3

Sodium 2-hydroxypentanedioate-2,3,3-d3 is the deuterium labeled α-Hydroxyglutaric acid disodium. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

12352211

Endogenous Metabolite; Histone Demethylase; Isotope-Labeled Compounds

Epigenetics; Metabolic Enzyme/Protease; Others

Cancer-programmed cell death

Cancer

O=C(CC([2H])(C([2H])(C(O[Na])=O)O)[2H])O[Na]

C5H3D3Na2O5

195.10

[1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19 (1) :17-30.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W704805/

Isotope-Labeled Compounds

No Development Reported