Natriumbutyraat (GMP)

Sodium butyrate (GMP) refers to Sodium butyrate of GMP grade. Small molecules of GMP grade can be used as adjuvants in cell therapy. Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity[1][2][3][4][5].

156-54-7

Butanoic acid (sodium) (GMP) ; Butyric acid (sodium) (GMP)

12352211

Apoptosis; Autophagy; Endogenous Metabolite; HDAC

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Cancer

CCCC(O[Na])=O

C4H7NaO2

110.09

[5]Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32 (4) :224-230|[1]Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13 (2) :921-929|[2]Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.|[3]Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14 (1) :34|[4]Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0350AG/

GMP Small Molecules

No Development Reported