Naxifylline
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Naxifylline (BG9719; CVT-124) is a potent and selective A1-adenosine antagonist with Ki values of 0.67 and 0.45 nM for rat and cloned human A1-receptors, respectively. Naxifylline is a potassium-sparing diuretic for the study of edema associated with congestive heart failure[1].
166374-49-8
BG9719; CVT-124
12352005
Adenosine Receptor
GPCR/G Protein
Neuroscience-Neuromodulation
Cardiovascular Disease
CCCN1C2=C(C(N(C1=O)CCC)=O)NC([C@@H]3[C@@]4([H])[C@@]5([H])[C@]([C@](C3)([H])C4)([H])O5)=N2
C18H24N4O3
344.41
[1]Pfister JR, et al. Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2- (5,6-epoxynorbonyl) ]-xanthine. J Med Chem. 1997 Jun 6;40 (12) :1773-8.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19240/
Reference compound1
Phase 3
Adenosine A1 receptor (A1R)
Beschrijving
Naxifylline (BG9719; CVT-124) is a potent and selective A1-adenosine antagonist with Ki values of 0.67 and 0.45 nM for rat and cloned human A1-receptors, respec
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