NC-002
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
NC-002, a cell-permeable peptide, is a Trypsin-like proteasome inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivative of Leupeptin. NC-002 sensitizes myeloma cells to Bortezomib (HY-10227) and Carfilzomib (HY-10455). NC-002 can be used for cancers research[1].
1356828-46-0
12352209
Proteasome
Metabolic Enzyme/Protease
Cancer
CC(C)C[C@H](NC(C)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C([C@]1(CO1)C)=O)=O)=O
C23H42N6O5
482.62
[1]Mirabella AC, et al. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011 May 27;18 (5) :608-18.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P11311/
Peptides
No Development Reported
Beschrijving
NC-002, a cell-permeable peptide, is a Trypsin-like proteasome inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivativ
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