NCIR2 Antilichaam - N-terminalgebied: HRP (ARP32464_T100-HRP)

Nuclear receptor corepressor 2

SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270, SMRTE-tau

9612

Q9Y618

NP_006303

Human, Mouse, Rat, Cow, Dog, Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human NCOR2

NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

HDAC4; HDAC3; RARA; HMGA1; HDAC2; HDAC1; AURKA; BCL6; BCOR; GPS2; ZBTB16; UBC; E2F1; NR1I2; BTRC; HDAC7; NR1H2; THRA; RUNX1; Pparg; Nr2f1; Nr1i3; Nr2f2; CBX6; C1D; NR1H4; NR1D1; Ppard; SUMO2; CTBP1; ARNT; AHR; NCOR1; AR; NRD1; E2F4; ZBTB7A; SOX2; ESR1; CE

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

NCOR2 is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 86%; Dog: 86%; Human: 100%; Mouse: 79%; Pig: 79%; Rat: 85%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

275kDa

Keeton, E.K. (2005) Mol. Endocrinol. 19 (6), 1543-1554

Wet Ice

2524

NCOR2

NCOR2

Rabbit

Nuclear receptor corepressor 2

NM_006312

DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEA