Nck1 Polyklonale Antilichaam, AbBy FluorTM 647 Vervoeging

Nck is a highly conserved, oncogenic protein. It is a common target for the action of different surface receptors, encoding one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase activating protein, phosphatidylinositol 3 kinase, and phospholipase Cg. Nck is widely expressed in various tissues and in cell lines from human, murine, and rat origins. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation of EGF and PDGF in A431 and NIH 3T3 cells respectively. Like other SH2 containing proteins, Nck is associated with tyrosine autophosphorylated EGF or PDGF receptors via its SH2 domain. Overexpression of Nck leads to transformation of NIH 3T3 cells.

NCK adaptor protein 2; Cytoplasmic protein NCK1; Melanoma Nck protein; MGC12668; NCK 1; Nck adaptor protein 1; NCK tyrosine kinase; NCK1; NCKalpha; Non catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK alpha; SH2/SH3 adaptor protein NCK alpha.

4690

Cytoplasm, Nucleus

31-150/377

Nck1

AbBy Fluor™ 647

KLH conjugated synthetic peptide derived from human Nck2

IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

650nm/665nm

1µg/µl

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

4690

Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Rabbit