NCLN Antilichaam

NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF-β superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.

56926

Q969V3

NP_064555

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

NCLN Antibody is affinity chromatography purified via peptide column.

Cat. No. 1401 - Mouse Heart Tissue Lysate

1 mg/mL

NCLN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NCLN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NCLN

Cat. No. 10-501 - Human Heart Tissue Slide

Nicalin

Homo sapiens

Haffner C, Frauli M, Topp S, et al. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J. 2004; 23:3041-50.

Dettmer U, Kuhn PH, Abou-Ajram C, et al. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J. Biol. Chem. 2010; 285:26174-81.

NCLN Antibody: NET59, Nicalin, Nicastrin-like protein

ELISA, WB, IHC-P, IF

51873031

Liquid