NCOA3 Antilichaam - middengebied: Biotine (ARP32487 P050-Biotine)

Nuclear receptor coactivator 3

ACTR, AIB1, RAC3, SRC3, pCIP, AIB-1, CTG26, SRC-3, CAGH16, KAT13B, TNRC14, TNRC16, TRAM-1, bHLHe42

8202

Q0VF45

NP_006525

Human, Mouse, Rat, Cow, Dog, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human NCOA3

NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

PSMB9; PPARG; CUL3; ARNT2; MMS19; FBXW7; SPOP; UBC; E2F1; PTEN; ESR2; ALB; NR1I2; THRB; CHUK; KANK2; ESR1; NR3C1; MYOCD; MKL1; MKL2; PSME3; UBE3A; TP53; RARA; MAPK1; PIN1; PGR; EP300; ELAVL1; MAPK14; CREBBP; CEBPD; CEBPA; TP53BP1; TFF1; PSMC5; PSMA3; PRKC

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

NCOA3 is strongly supported by BioGPS gene expression data to be expressed in MCF7

0.5 mg/ml

Cow: 77%; Dog: 90%; Horse: 92%; Human: 100%; Mouse: 83%; Pig: 92%; Rat: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

155kDa

Luo, J.H., (2008) Int. J. Cancer 122 (11), 2554-2561

Wet Ice

1420

NCOA3

NCOA3

Rabbit

Nuclear receptor coactivator 3

NM_006534

DQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLL