NDI-Lyso
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
2999646-19-2
Apoptosis, Caspase
Proteases/Proteasome, Apoptosis
NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis) . NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM) .
O=C1C=2C3=C4C(C(=O)N(CCCCCC)C(=O)C4=CC2)=CC=C3C(=O)N1CCC(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CC6=CC=CC=C6)=O
C71H100N22O13
1469.69
Ice Packs
-20°C
Beschrijving
NDI-Lyso Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
Recent bekeken producten
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Drug Stability Chamber
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1 Unit
Modular Incubator Chamber
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CYP707A2 Antibody
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SsDNA Assay Kit
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100 Tests
Eco Alu MTP (HxD) 6x7=42 plates 35mm, 223x630x135mm
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Arachis hypogaea Lectin (PNA) - Biotinylated
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Cellubrevin Antibody
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Recent gezochte producten
MARV VP40/Marburg VP40 Protein (N-His, Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980) ) )
P505862
100 µg
BDBV Nucleoprotein Recombinant Protein (N-His)
VK059012-01
50 µg
KBFP720 700L Stability Chamber
CHA3020
1 Each
KBFLQC240 247L Stability Chamber
CHA3022
1 Each
KBF1020 1020L Stability Chamber
CHA3024
1 Each
Stability Chamber KBFP240 247L
CHA3030
1 Each
Drug Stability Chamber
150-DSC100
1 Unit
Drug Stability Chamber
150-DSC200
1 Unit