NEDD4L Antilichaam - middengebied: Biotine (ARP43192 P050-Biotine)

Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

RSP5, PVNH7, NEDD4-2, NEDD4.2, hNEDD4-2

23327

Q96PU5-5

NP_056092

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human NEDD4L

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

NEDD4L; DAZAP2; UBE2D1; PTCH1; WNK3; TNK2; SNCA; SLC9A3; SMAD6; KCNH2; HCN1; SMAD3; UBE2N; SNA3; NOTCH1; UBE2D3; UBC; SGK1; KCNQ1; SGK3; GORAB; MED28; FBXL15; vpr; RNF11; AATF; YWHAQ; LAPTM5; SCNN1B; SMAD2; ARRDC3; ARRDC4; UBE2L3; UBE2D2; SMAD7; UBE2K; UB

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

110kDa

Raikwar, N.S. Am. J. Physiol. Renal Physiol. 294 (5), F1157-F1165 (2008)

Wet Ice

955

NEDD4L

NEDD4L

Rabbit

E3 ubiquitin-protein ligase NEDD4-like

NM_015277

TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP