Neosakuranine

Neosakuranin is a flavonoid. Neosakuranin can be isolated from Sorbus commixta and the bark of P. cerasus. Neosakuranin exhibits suppressive effects on xanthine oxidase with an IC50 of 157.8 μM. Neosakuranin inhibits COX-l. Neosakuranin can be used in the research of inflammatory diseases[1][2][3].

31187-54-9

12352005

COX; Xanthine Oxidase

Immunology/Inflammation; Metabolic Enzyme/Protease

Inflammation/Immunology

OC(C=C1)=CC=C1/C=C/C(C2=C(C=C(C=C2O)OC)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O

C22H24O10

448.42

[1]Matsuoka N, et al. Study of the chemical constituents of Pruni Cortex and its related parts. J Nat Med. 2011 Jan;65 (1) :166-71. |[2]Bhatt LR, et al. A chalcone glycoside from the fruits of Sorbus commixta Hedl. Molecules. 2009 Dec 16;14 (12) :5323-7. |[3]Zhang X, et al. Anti-inflammatory activity of flavonoids from Populus davidiana. Arch Pharm Res. 2006 Dec;29 (12) :1102-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N17699/

Natural Products

No Development Reported

COX-1