Neospiramycine I

Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I. Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus, but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations (MIC) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae, with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli, with an inhibitory concentration 50 (IC50) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg[1][2].

70253-62-2

12352005

H302-H315-H319-H335

Antibiotic; Bacterial

Anti-infection

Infection

O=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)O

C36H62N2O11

698.88

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Sano H, et al. Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12- (Z) -isomers. J Antibiot (Tokyo) . 1984 Jul;37 (7) :738-49.|[2]Sano H, et al. Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I. J Antibiot (Tokyo) . 1983 Oct;36 (10) :1336-44.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W587414/

Reference compound1

No Development Reported