NEPP11

NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion[1].

313051-12-6

12352005

Apoptosis; Drug Derivative; ERK; Keap1-Nrf2; MEK; Raf

Apoptosis; MAPK/ERK Pathway; NF-κB; Others; Stem Cell/Wnt

Inflammation/Immunology; Neurological Disease

C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2

C26H36O3

396.57

[1]Shibata S, et al. Prevention of oxytosis-induced c-Raf down-regulation by (arylthio) cyclopentenone prostaglandins is neuroprotective. Toxicology. 2017 Sep 1;390:83-87.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180327/

Reference compound1

No Development Reported

C-Raf; ERK1; ERK2; MEK1; MEK2