Netropsin

Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity[1][2].

1438-30-8

12352005

H301

Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus; Orthopoxvirus

Anti-infection; Cell Cycle/DNA Damage

Infection; Inflammation/Immunology

O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2

C18H26N10O3

430.46

P264-P270-P330-P405-P501

[1]Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090 (1) :52-60.|[2]Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73 (1) : 341-343.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N6800/

Natural Products

No Development Reported